Infusion Billing Simplified: Understanding CPT 96365
Clear guidance on CPT 96365 for accurate infusion billing, documentation, and claims support by Billing Care Solutions.

Infusion billing is probably one of the most detailed and time-sensitive aspects of the whole medical billing process. Due to the fact that there are very strict regulations, time-based calculations, and multiple code options, both billers and providers need to be absolutely sure of the way they select the proper CPT code for each service. One of the most important CPT codes in the set of infusion codes is definitely the 96365. It is the code for the first hour of a therapeutic or prophylactic IV infusion and, essentially, it is the basis of most scenarios in infusion billing.
Billers, coders, and healthcare providers are all confused about the 96365, and this misunderstanding is very often the reason for denied claims or incorrect reimbursement. This guide will help you understand and apply CPT 96365 with confidence by simplifying the process and providing real billing situations.
What Is CPT 96365?
CPT 96365 is the code that is utilized for the first hour of an intravenous infusion of a therapeutic, prophylactic, or diagnostic substance. It is the code that should be used when a medication is given via an IV and the time of the infusion is more than 15 minutes but less than or equal to one hour.
The official CPT description defines 96365 as the service that is performed first. In other words, this code should be billed only once per patient encounter for the main infusion service, and if there is more infusion time or additional drugs, then add-on codes should be used. The code CPT 96365 is only for non-chemotherapy medications. Different codes are used for chemotherapy administration because of its complexity and higher risks.
The significance of knowing 96365 starts with the fact that it indicates the highest level of therapeutic infusion during the encounter, and it is the anchor code that everything else is built upon.
Common Billing Scenarios Involving CPT 96365
| Scenario | Infusion Details | Billing Codes |
|---|---|---|
| One Hour Single Drug Infusion | Ceftriaxone infused from 1:00 PM to 2:00 PM (60 minutes) | 96365 for the initial hour |
| Infusion Plus Sequential Infusion | Vancomycin 10:00 AM to 11:00 AM (60 minutes) Zosyn 11:00 AM to 11:20 AM (20 minutes) | 96365 initial infusion 96367 sequential infusion |
| Infusion Plus IV Push | Vancomycin infused for 50 minutes Toradol given as IV push | 96365 initial infusion 96375 IV push new drug |
| Hydration Plus Therapeutic Infusion | Hydration 25 minutes (not billable) Iron infusion 45 minutes | 96365 for therapeutic infusion only |
| Concurrent Infusions | Two antibiotics infused together for 60 minutes | 96365 initial infusion 96368 concurrent infusion |
When to Use CPT 96365
| Category | Details |
|---|---|
| Minimum Time Requirement | Infusion must run at least 16 minutes. Anything less is not billable as an infusion. |
| Type of Service | Therapeutic or prophylactic IV infusion (non chemotherapy). |
| Typical Drugs Billed With 96365 | • Antibiotics such as Rocephin or Vancomycin • Iron infusions • Steroid infusions • Pain medication infusions • Antiviral or antifungal infusions |
| Hierarchy Rules (Order of Initial Code Selection) |
1. Chemotherapy or complex biologic infusion 2. Therapeutic or prophylactic infusion (this is where 96365 belongs) 3. Hydration infusion |
| When 96365 Is the Initial Code | When the patient receives a therapeutic IV infusion and no chemotherapy or higher-level infusion is performed. |
| Do NOT Use CPT 96365 For |
• Hydration fluids • IV push medications • Subcutaneous infusions • IM injections • Infusions less than 16 minutes |
Related Codes That Are Used Along with CPT 96365
CPT 96365 alone is just the first step in multi-hour or multi-drug infusion situations. Based on the duration and kind of infusion, there may also be some additional codes that have to be used.
CPT 96366:
It is the code for every extra hour of a therapeutic infusion after the first one. Also, at least 31 minutes beyond the first hour must be recorded.
CPT 96367:
It is a code that is used to represent the sequential additional infusion of a different drug through the same IV line. Moreover, the time of infusion should be at least 16 minutes.
CPT 96368:
This code is used when a second substance is infused concurrently and it is a continuation of the first infusion line.
Billing professionals must be aware of the way each of these additional codes relates to the hierarchical structure of the infusion, and they should use them only when supported by the time and documentation provided.
Common Mistakes When Billing CPT 96365:
Sometimes, even skillful billers make infusion billing mistakes. Here is a list of the most frequent issues that cause carriers to refuse payment:
- Charging 96365 when the infusion was under 16 minutes
- Turning to hydration codes while administering therapeutic infusion codes
- Lack of or incomplete documentation of start and stop times
- Wrong choice of the initial service code
- Billing additional hours without completing the 31-minute minimum
If one refrains from making these errors, then the clean claim submission rate goes up and the payment for infusion services is enhanced.
Reimbursement Insights for CPT 96365:
The money returned for CPT 96365 can be different for different types of payers, rates of contracts, and regions of the earth. As a rule of thumb, treatment infusions such as 96365 are paid for at a higher level than rehydration but at a lower level than chemotherapy infusion services.
It is very important to have precise documentation and the right coding because if only one claim is denied, it may be necessary to resubmit it several times, thus the payment may be delayed for several weeks. Those practices that are proficient in the billing of infusions usually experience significantly higher rates of approvals and fewer issues with payers.
Summary and Key Takeaways
CPT 96365 represents the main code for the first hour of a therapeutic or prophylactic intravenous infusion (IV) service. The billing should be done correctly only when the infusion is running for at least 16 minutes, and the full documentation of the start and stop times is available. In addition to CPT 96365, Understanding the use of add-on codes such as 96366, 96367, and 96368 will ensure that the billing is done correctly and the risk of denials is kept at a minimum.
If a practice is after clean claims, fewer rejections, and higher reimbursement, then they must apply the CPT hierarchy rules, document properly, and use time-based guidelines.
Billing Care Solutions is a great assistance for healthcare providers who want to simplify infusion billing, stay compliant, and increase their revenue by receiving expert coding and billing support.
There is no need for the billing of infusion services to be a complicated process. Your organization can, with the right approach and the assistance of BCS, achieve accurate coding, timely payments, and improved workflow efficiency.


